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2013 Fiscal Year Final Research Report

Mechanism of fate desicion between immune regulation and immune aggravation

Research Project

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Project/Area Number 24790458
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionTohoku University

Principal Investigator

MARUYAMA TAKASHI  東北大学, 生命科学研究科, 助教 (10622524)

Co-Investigator(Renkei-kenkyūsha) MUTA Tatsushi  東北大学, 大学院生命科学研究科, 教授 (60222337)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords免疫恒常性 / 制御性T細胞
Research Abstract

IkB-family protein, IkB-zeta located into nuclear, and control NF-kB target gene expression. IkB-zeta deficient (KO) mice caused autoimmune like sjogren's syndrome with age.
Thus, we hypothesis that KO mice have problem about the suppressor ability, stability or generation of regulatory T cells (Treg).
We found that regulatory T cells (Tregs) from KO mice has less suppression ability compared with control mice. We also found that stability of Tregs were comparable between control and KO mice. In addition, IkB-zeta plays an pivotal role for Tregs fate desition.

  • Research Products

    (3 results)

All 2013

All Presentation (3 results)

  • [Presentation] Control of the differentiation of regulator T cells by the transcriptional regulator IκB-ζ2013

    • Author(s)
      Maruyama Takashi & Muta Tatsushi
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      千葉
    • Year and Date
      2013-12-13
  • [Presentation] Critical roles for the transcriptional regulator IκB-ζin regulatory T cells2013

    • Author(s)
      Maruyama Takashi & Muta Tatsushi
    • Organizer
      ICI2013 (15^<th> International Congress of Immunology)
    • Place of Presentation
      イタリア、ミラノ
    • Year and Date
      2013-08-25
  • [Presentation] 核内IκBタンパク、IκB_<NS>によるTh17産生制御2013

    • Author(s)
      小林修平、牟田達史、丸山貴司
    • Organizer
      第134年会、日本薬学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-03-30

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Published: 2015-06-25  

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