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2013 Fiscal Year Final Research Report

Identification of mechanisms controlling memory Th17 cell generation in steroid-resistant asthma

Research Project

  • PDF
Project/Area Number 24790460
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

SUZUKI Akane  千葉大学, 医学(系)研究科(研究院), 特任助教 (90586603)

Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsメモリーTh17細胞 / ステロイド抵抗性喘息
Research Abstract

We identified the two candidate genes regulating memory Th17 cell generation by cDNA microarray analysis of effector cells that become memory cells. To clarify the mechanism that control memory Th17 cell generation by the candidate molecules is important for establishment of a basis for the treatment of neutrophilic and steroid-resistant Th17 dependent asthma.

  • Research Products

    (6 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The polycomb protein Ezh2 regulates differentiation and plasticity of CD4^+ T helper type 1 and type 2 cells2013

    • Author(s)
      Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.
    • Journal Title

      Immunity

      Volume: 39(5) Pages: 819-832

    • DOI

      10.1016/j.immuni.2013.09.012

    • Peer Reviewed
  • [Presentation] Induction of anti-tumor effect of BCG-LM through activation of eosinophils and effector memory Th2 cells2013

    • Author(s)
      Ito, T., Hirahara, K., Suzuki, A., Shinoda, K., Hayashizaki, K., Wada, T., Yano, I., and Nakayama, T.
    • Organizer
      第42回日本免疫学会総会学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2013-12-11
  • [Presentation] The histone methyltransferase Ezh2 regulates differentiation and plasticity of CD4 T helper cells2013

    • Author(s)
      Tumes, D., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., and Nakayama, T.
    • Organizer
      AAI Annual Meeting
    • Place of Presentation
      Hawaii Convention Center (Honolulu, Hawaii, USA)
    • Year and Date
      2013-05-06
  • [Presentation] Regulation of memory CD4 T cell pool size and function by NKT cells in vivo2012

    • Author(s)
      Iwamura, C., Endo, Y., Onodera, A., Watanabe, Y., Suzuki, A., Kinjo, Y., and Nakayama, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2012-12-06
  • [Presentation] GATA3/Ruvbl2複合体によるCdkn2c (p18, Ink4c)の転写制御を介したTh2細胞増殖制御メカニズムの解析2012

    • Author(s)
      細川裕之、田中知明、加藤美紀、遠山裕之、鈴木茜、中山俊憲
    • Organizer
      第22回Kyoto T cell Conference
    • Place of Presentation
      和順会館(京都府京都市)
    • Year and Date
      2012-07-07
  • [Patent(Industrial Property Rights)] 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物2013

    • Inventor(s)
      中山俊憲、細川裕之(国立大学法人 千葉大学)、常世田好司(ドイツリュウマチ研究センター)、林﨑浩史、鈴木茜(国立大学法人千葉大学)
    • Industrial Property Rights Holder
      国立大学法人千葉大学
    • Industrial Property Rights Type
      特願
    • Industrial Property Number
      2013-114388
    • Filing Date
      2013-05-30

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Published: 2015-06-25  

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