2013 Fiscal Year Final Research Report
Expressional and functional analysis of FROUNT in mice
| Project/Area Number |
24790462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TERASHIMA Yuya 東京大学, 医学(系)研究科(研究院), 助教 (90538729)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 白血球遊走 |
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| Research Abstract |
FROUNT binds to the intracellular region of chemokine receptors CCR2 and CCR5, which are involved in the various inflammatory diseases. FROUNT promotes CCR2/CCR5-mediated chemotaxis by regulating PI3K/Rac/lamellipodium cascade.
In this study, we generated FROUNT-genetically modified mice. These new tools enabled us to investigate biological function of FROUNT under physiological conditions. We identified that FROUNT is highly expressed on monocytes/macrophages and regulates chemotaxis of these cells in mice. Future studies of FROUNT using these new tools in the various disease models will help us to understand the regulatory mechanisms of immune and inflammatory system.
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[Journal Article] Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR52014
Author(s)
Toda E, Terashima Y, Esaki K, Yoshinaga S, Sugihara M, Kofuku Y, Shimada I, Suwa M, Kanegasaki S, Terasawa H, Matsushima K
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Journal Title
Biochem J
Volume: 457(2)
Pages: 313-22
DOI
Peer Reviewed
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