2013 Fiscal Year Final Research Report
The roles of nuclear IkappaB protein in the regulation of B cell function
| Project/Area Number |
24790466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Niigata University |
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Principal Investigator |
TOUMA Maki 新潟大学, 自然科学系, 助教 (40542246)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | リンパ球 / 転写因子 |
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| Research Abstract |
A transcription factor nuclear factor-kappaB (NF-kappaB) plays an essential role in the overall regulation of the immune system and inflammatory responses. Activation of NF-kappaB is tightly regulated by inhibitory proteins termed IkappaB, which consist of classical cytoplasmic and nuclear IkappaBs. Roles of a nuclear regulator of NF-kappaB, IkappaBNS, in the development and function of B cells were studied. We have found that IkappaBNS is important for proliferative activity and antibody production via Toll-like receptor signals. IkappaBNS is also involved in the development of regulatory B cells that produce anti-inflammatory cytokine IL-10. Thus, an additional important role for IkappaBNS in control of the immune response was defined.
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