Endothalial cell-derived IL-7 controls B cell development and peripheral T cell maintenance

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790468
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Kyoto University
• Principal Investigator: HARA Takahiro 京都大学, ウイルス研究所, 助教 (90512301)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: サイトカイン / IL-7 / 内皮細胞 / T細胞 / Ｂ細胞

Research Abstract

IL-7 is an essential cytokine for the development, proliferation and survival of lymphocytes. However, the precise distribution and the local function of IL-7-expressing cells are largely unknown. In this research project, I aimed to clarify the effects of IL-7 produced by lymphatic endothelial cells and bone marrow endothelial cells on peripheral T cells and bone marrow B cells. By using endothelial cell specific IL-7 deleted mice, I found that endothelial cell-derived IL-7 controls the peripheral T cell migration and bone marrow B cell development.

Research Products

• [Journal Article] IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCRγδ+ Intraepithelial Lymphocytes (2013)
  • Author(s): Soichiro Shitara, Takahiro Hara, Bingfei Liang, Keisuke Wagatsuma, Saulius Zuklys, Georg A. Hollander, Hiroshi Nakase, Tsutomu Chiba, Shizue Tani-ichi, and Koichi Ikuta
  • Journal Title: The Journal of Immunology Volume: 190(12) Pages: 6173-6179
  • DOI: 10.4049/jimmunol.1202573
  • Peer Reviewed
• [Journal Article] B cell progenitors and precursors change their microenvironment in fetal liver during early development (2013)
  • Author(s): Motokazu Tsuneto, Koji Tokoyoda, Ekaterina Kajikhina, Anja E. Hauser, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta and Fritz Melchers
  • Journal Title: Stem Cells Volume: 31 Pages: 2800-2812
  • DOI: 10.1002/stem.1421
  • Peer Reviewed
• [Journal Article] CD49b-dependent establishment of T helper cell memory (2013)
  • Author(s): Asami Hanazawa, Koji Hayashizaki, Kenta Shinoda, Hideo Yagita, Ko Okumura, Max Löhning, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta, Beate Eckes, Andreas Radbruch, Koji Tokoyoda and Toshinori Nakayama
  • Journal Title: Immunol Cell Biol Volume: 91 Pages: 524-531
  • DOI: 10.1038/icb.2013.36
  • Peer Reviewed
• [Journal Article] The interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations (2013)
  • Author(s): Shizue Tani-ichi, Akihiro Shimba, Keisuke Wagatsuma, Hitoshi Miyachi, Satsuki Kitano, Kumiko Imai, Takahiro Hara, and Koichi Ikuta
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Pages: 612-617
  • DOI: 10.1073/pnas.1219242110
  • Peer Reviewed
• [Journal Article] IL-7産生細胞のリンパ組織内分布 (2013)
  • Author(s): 原崇裕、生田宏一
  • Journal Title: 医学のあゆみ Volume: Vol.246、No.12 Pages: p.1055-p.1056
• [Journal Article] Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice (2012)
  • Author(s): Takahiro Hara, Soichiro Shitara, Kumiko Imai, Hitoshi Miyachi, Satsuki Kitano, Hisayuki Yao, Shizue Tani-ichi, Koichi Ikuta
  • Journal Title: The Journal of Immunology Volume: 189(4) Pages: 1577-84
  • DOI: 10.4049/jimmunol.1200586
  • Peer Reviewed
• [Journal Article] Role of Hepatocyte-Derived IL-7 in Maintenance of Intrahepatic NKT Cells and T Cells and Development of B Cells in Fetal Liver (2012)
  • Author(s): Bingfei Liang, Takahiro Hara, Keisuke Wagatsuma, Jia Zhang, Kazushige Maki, Hitoshi Miyachi, Satsuki Kitano, Chihiro Yabe-Nishimura, Shizue Tani-ichi, and Koichi Ikuta
  • Journal Title: The Journal of Immunology Volume: 189(9) Pages: 4444-4450
  • DOI: 10.4049/jimmunol.1201181
  • Peer Reviewed
• [Presentation] Visualization and characterization of IL-7- and IL-15-expressing cells in vivo (2013)
  • Author(s): Takahiro Hara, Guangwei Cui, and Koichi Ikuta
  • Organizer: International Workshop of Kyoto T Cell Conference 2013
  • Place of Presentation: 京都大学芝蘭会館
  • Year and Date: 20130603-07
• [Presentation] Distribution and function of IL-7-expressing cells in intestines (2013)
  • Author(s): Takahiro Hara, Guangwei Cui, Soichiro Shitara, and Koichi Ikuta
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2013-12-11
• [Remarks]
  • URL: http://www.virus.kyoto-u.ac.jp/Lab/ikuta.html