2013 Fiscal Year Final Research Report
Analysis of the peripheral T cell function by using IL-7R conditional knockout mice
| Project/Area Number |
24790469
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | T細胞 / IL-7レセプター / TCR |
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| Research Abstract |
Little is known about the roles of IL-7 signal in the peripheral T cell function. To address this question, we used peripheral naive T cells from IL-7 receptor (IL-7R) conditional knockout mice or mutant mice of IL-7R-regulatory region and analyzed their TCR responsiveness. We found the possibility that IL-7 signal in naive T cells is required for the proliferation when these T cells are activated by TCR stimulation, and there is positive correlation between IL-7R expression levels on naive T cells and their TCR responsiveness at least in vitro. In addition, we found that regulatory T cells (Tregs) from IL-7R conditional knockout mice show weak suppression activity compared to that of wild-type mice derived Tregs in vitro.
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[Journal Article] CD49b-depend -ent establishment of T helper cell memory2013
Author(s)
Hanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Löhning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, Nakayama T
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Journal Title
Immunol Cell Biol
Volume: 91(8)
Pages: 524-531
DOI
Peer Reviewed
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