2013 Fiscal Year Final Research Report
Novel mechanism for the regulation of lymphocyte dynamics
| Project/Area Number |
24790470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
SUZUKI Kazuhiro 大阪大学, 免疫学フロンティア研究センター, 准教授 (60611035)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ケモカイン受容体 / シグナル伝達 / 免疫細胞動態 |
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| Research Abstract |
We identified COMMD3 as a novel regulator of chemoattractant receptor signaling. In this study, we aimed at clarifying a novel mechanism for the regulation of lymphocyte dynamics through functional analysis of COMMD3. By analyzing gene-targeted mice, we found that COMMD3 acts as a positive regulator of sphingosine 1-phosphate receptor S1P1 and promotes T cell exit from the thymus.
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