The novel molecular mechanism regulating the Inflammation Amplifier

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790472
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Hokkaido University (2014); Osaka University (2012-2013)
• Principal Investigator: OGURA Hideki 北海道大学, 遺伝子病制御研究所, 特任助教 (20573174)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: NF-kB / 炎症アンプ

Outline of Final Research Achievements

Inflammation amplifier (IL-6 amplifier) is the key mechanism involved in chronic inflammation. In non-hematopoietic cells including fibroblasts or vascular endothelial cells, NF-kB activation together with STAT3 activation hyperactivates NF-kB signaling. Knowing the amplifier is shown to be important for the pathogenesis of autoimmune diseases or chronic graft rejection model, it is important to study the molecular basis of this mechanism, as it is a promising target for drug development. In this study, we found that ZFP1 regulates inflammation amplifier via regulating NF-kB DNA binding activity. We also identified kinase X regulating NF-kB promoter recruitment.

Free Research Field

自己免疫