2013 Fiscal Year Final Research Report
Identification of functional relationship between the ILCs and the mast cells in the small intestine
| Project/Area Number |
24790474
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
LEE YOUNGAE 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (60610681)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | IL-22 / IL-17F / DEFAs / Innate lymphoid cells / Mast cells |
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| Research Abstract |
We found that the IL-7Ra+ population (CD4- LTi-like cells) within Lin-c-Kit+NKp46-CD4- cells has a protective role against bacterial infection through high expression of IL-17F and IL-22. The strong expression of DEFAs by the IL-7Ra-CD34-b7int population in the steady-state condition may play an important role in maintaining tissue homeostasis with commensal bacteria. IL-7Ra-CD34+b7int and IL-7Ra-CD34intb7hi cells are MCPs, which can differentiate into MCs that may regulate inflammatory responses by expressing high levels of MCPT5 and CPA3.
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