Is rehabilitation effective for the high-dose radiation induced disorder of skin and muscle in rats?

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790495
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical sociology
• Research Institution: Hirosaki University
• Principal Investigator: NARITA Hirokazu 弘前大学, 医学(系)研究科(研究院), 助教 (90455733)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線障害 / リハビリテーション / トレッドミル走行 / 皮膚 / 筋

Outline of Final Research Achievements

The aim of this study was to demonstrate the effect of rehabilitation (treadmill exercise) on the high-dose radiation induced disorder of skin and muscle in rats. Rats were locally irradiated to the hind limbs and randomly allocated into a control group, 50-Gy X-irradiation group and 50-Gy X-irradiation with treadmill exercise group. At 7 weeks after the irradiation, skin and muscle of the rat’s hind limbs were histologically examined. As a result, the treadmill exercise was effective to maintain the thickness of the muscle fibers after irradiation. In contrast, in the skin, the exercise was thought to be detrimental because the degree of tissue degeneration with vascular alteration became worse. Therefore, it is necessary to choose a suitable rehabilitation approach depending on the severity, target region and stage of the radiation induced disorder.

Free Research Field

解剖学