2016 Fiscal Year Final Research Report
The role of a membrane-bound glutathione transferase in the oxidative stress-induced mitochondria dysfunction
| Project/Area Number |
24790533
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Keywords | グルタチオントランスフェラーゼ / ミトコンドリア / 透過性遷移 / 酸化ストレス |
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| Outline of Final Research Achievements |
In the present study, we aimed to confirm the role of mtMGST1 in the oxidative stress-induced mitochondrial permeability transition (MPT) pore opening. We found that the inner membrane mtMGST1 and MPT regulator proteins such as ANT and CypD are involved in the oxidant peroxynitrite (PON)-induced MPT pore opening, which is mediated by a disulfide bond, and that PON induces mitochondrial swelling accompanied by formation of high molecular weight proteins complex (MPC) of mtMGST1, ANT, and CypD via caldiolipin(CL), which is a phospholipid exclusively located in mitochondria.
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| Free Research Field |
臨床検査
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