2013 Fiscal Year Final Research Report
Development of novel biomarkers for early detection of diabetic nephropathy
| Project/Area Number |
24790535
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 糖尿病性腎症 / バイオマーカー / Kim-1 / OLETFラット / 腎臓学 |
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| Research Abstract |
Using spontaneous type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, we examined temporal pattern of novel tubular markers in the urine for early diagnosis and evaluation of the severity of diabetic nephropathy. Urinary kidney injury molecule-1 (Kim-1) showed significant elevation before increase in albuminuria and N-acetyl-beta-D-glucosaminidase (NAG) in the OLETF rats with histopathologically proven renal tubular injury, compared with non-diabetic controls, Long-Evans Tokushima Otsuka (LETO) rats. In addition, urinary human KIM-1 showed elevation in type 2 diabetic patients with nephropathy compared with nondiabetic patients. Thus, urinary Kim-1 is a useful biomarker for the detection of early stage of type 2 diabetic nephropathy.
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[Journal Article] Dosing time - dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post - menopausal women with osteoporosis2013
Author(s)
Ando H, Otoda T, Ookami H, Nagai Y, Inano A, Takamura T, Ushijima K, Hosohata K, Matsushita E, Saito T, Kaneko S, Fujimura A
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Journal Title
Clin Exp Pharmacol Physiol
Volume: 40
Pages: 227-232
Peer Reviewed
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