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2013 Fiscal Year Final Research Report

Antimicrobial Susceptibility and Molecular Epidemiology of Drug Resistance in S. maltophilia

Research Project

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Project/Area Number 24790546
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionTohoku University

Principal Investigator

KANAMORI HAJIME  東北大学, 大学病院, 助教 (70625318)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords感染症 / S. maltophilia / 薬剤感受性 / Smqnr
Research Abstract

Stenotrophomonas maltophilia infections are difficult to treat as the bacterium exhibits high-level intrinsic resistance to a variety of antimicrobial agents. Smqnr have been recently identified in S. maltophilia as a novel chromosomal quinolone resistance gene. In this study, we investigated the antimicrobial susceptibility and the prevalence of Smqnr among S. maltophilia isolates in Japan. Resistance rates to ceftazidime, levofloxacin, trimethoprim-sulfamethoxazole, and minocycline were 67%, 6%, 18%, and 0%, respectively. Smqnr was detected at high frequencies in S. maltophilia isolates (approximately 60%), and there were regional differences in Smqnr frequency. In this study, we described novel variants of Smqnr.

  • Research Products

    (10 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Tuberculosis exposure among evacuees at a shelter after earthquake2013

    • Author(s)
      Kanamori H, Aso N, Tadano S, Saito M, Saito H, Uchiyama B, Ishibashi N, Inomata S, Endo S, Aoyagi T, Hatta M, Yamada M, Gu Y, Tokuda K, Yano H, Kunishima H, Hirakata Y, Saijyo T, Kitagawa M, Kaku M
    • Journal Title

      Emerg Infect Dis

      Volume: 19 Pages: 799-801

    • DOI

      10.3201/eid1905.121137.

    • Peer Reviewed
  • [Journal Article] Molecular characteristics of extended-spectrumβ-lactamases in clinical isolates from Escherichia coli at a Japanese tertiary hospital2013

    • Author(s)
      Yano H, Uemura M, Endo S, Kanamori H, Inomata S, Kakuta R, Ichimura S, Ogawa M, Shimojima M, Ishibashi N, Aoyagi T, Hatta M, Gu Y, Yamada M, Tokuda K, Kunishima H, Kitagawa M, Hirakata Y, and Kaku M
    • Journal Title

      PLoS One

      Volume: 8 Pages: 64359

    • DOI

      10.1371/journal.pone.0064359.

    • Peer Reviewed
  • [Journal Article] Lessons learned from a tuberculosis contact investigation associated with a disaster volunteer after the 2011 Great East Japan Earthquake2013

    • Author(s)
      Kanamori H, Uchiyama B, Hirakata Y, Chiba T, Okuda M, Kaku M
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 187 Pages: 1278-1279

    • DOI

      10.1164/rccm.201212-2150LE.

    • Peer Reviewed
  • [Journal Article] Molecular characteristics of extended-spectrumβ-lactamases and qnr determinants in Enterobacter species from Japan2012

    • Author(s)
      Kanamori H, Yano H, Hirakata Y, Hirotani A, Arai K, Endo S, Ichimura S, Ogawa M, Shimojima M, Aoyagi T, Hatta M, Yamada M, Gu Y, Tokuda K, Kunishima H, Kitagawa M, Kaku M
    • Journal Title

      PLoS One

      Volume: 7 Pages: 37967

    • DOI

      10.1371/journal.pone.0037967.

    • Peer Reviewed
  • [Journal Article] High frequency of IMP-6 among clinical isolates of metallo-β-lactamase-producing Escherichia coli in Japan2012

    • Author(s)
      Yano H, Ogawa M, Endo S, Kakuta R, Kanamori H, Inomata S, Ishibashi N, Aoyagi T, Hatta M, Gu Y, Yamada M, Tokuda K, Kunishima H, Kitagawa M, Hirakata Y, Kaku M
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 56 Pages: 4554-4555

    • DOI

      10.1128/AAC.00617-12.

    • Peer Reviewed
  • [Journal Article] Descriptive analysis of healthcare-associated infections other than bloodstream, respiratory, urinary tract, or surgical site infections2012

    • Author(s)
      Kanamori H, Weber DJ, Sickbert-Bennett EE, Brown V, Kaku M, Rutala WA
    • Journal Title

      Infect Control Hosp Epidemiol

      Volume: 33 Pages: 1276-1278

    • DOI

      10.1086/668423.

    • Peer Reviewed
  • [Presentation] 本邦におけるStenotrophomonas maltophiliaのSmqnrに関する検討2014

    • Author(s)
      金森肇、田内絢子、矢野寿一、遠藤史郎、小川美保、霜島正浩、賀来満夫
    • Organizer
      第25回日本臨床微生物学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-02-01
  • [Presentation] Role of Clinical Laboratory Test and Lessons Learned from Infection Control and Prevention in the Affected Area2013

    • Author(s)
      Kanamori H, Nagasawa M, Endo S, Aoyagi T, Hatta M, Gu Y, Tokuda K, Yano H, Kaku M
    • Organizer
      The 7th Asian Conference on Emergency Medicine
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-10-25
  • [Presentation] Clinical Characteristics of Active Pulmonary Tuberculosis after the 2011 Great East Japan Earthquake2013

    • Author(s)
      Kanamori H, Aso N, Uchiyama B, Saito H, Hirakata Y, Kaku M
    • Organizer
      IDWeek2013
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2013-10-05
  • [Presentation] Application of phage open-reading frame typing to methicillin-resistant Staphylococcus aureus outbreak investigations in a Japanese tertiary care hospital2012

    • Author(s)
      Kanamori H, Tokuda K, Inomata S, Saito M, Ikeda S, Yano H, Kunishima H, Kitagawa M, and Kaku M
    • Organizer
      8th International Healthcare Infection Society (HIS) Conference and Federation of Infection Societies (FIS) annual conference
    • Place of Presentation
      Liverpool, UK
    • Year and Date
      2012-11-19

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Published: 2015-06-25  

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