2013 Fiscal Year Final Research Report
The challenge to underlying causes of steroid insensitivity in bronchial asthma and its clinical application
| Project/Area Number |
24790547
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University (2013)
Akita University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ステロイド抵抗性 / ホスファターゼ / 気管支喘息 / ステロイド受容体 |
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| Research Abstract |
We examined the involvement of protein phosphatases as underlying causes of steroid insensitivity in severe asthma. We focused on phosphatases other than the phosphatase recently reported by us, and revealed that their protein expression levels were reduced in the cells obtained from severe asthmatics. We have optimized the detection methods of them in each cell by using imaging flow cytometer. In addition, the association between their expression levels and practical steroid insensitivity is under study, which might lead to a clinical application in future.
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