Molecular mechanism of mitophagy and its application to the laboratory medicine

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790556
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Kyushu University
• Principal Investigator: AOKI Yoshimasa 九州大学, 大学病院, 主任臨床検査技師 (80419514)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: マイトファジー / ミトコンドリア

Outline of Final Research Achievements

Mitophagy is a process that degrade mitochondria selectively. In this study, we investigated the signaling pathways that regulate mitophagy using yeast and human cell lines. We further try to establish the method to detect the mitophagy using clinical laboratory test. We found that, in human cells, MAP kinase Erk2 and p38 related signaling pathways are important for mitophagy. In addition, we found that mitophagy dispensable protein Atg32 is expressed under the regulation of TOR and the down Ume6-Sin3-Rpd3 complex.

Free Research Field

病態検査学