Comprehensive study for detection of coronary endothelial dysfunction using microRNA array analysis

2015 Fiscal Year Final Research Report

• Project/Area Number: 24790559
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Nagoya City University
• Principal Investigator: Sugiura Tomonori 名古屋市立大学, 医学(系)研究科(研究院), 助教 (60535235)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 動脈硬化 / マイクロRNA / 血管内皮 / 酸化ストレス / 高血圧 / 喫煙 / 脂質異常 / 冠動脈

Outline of Final Research Achievements

Vascular endothelial damage was improved and plasma levels of circulating microRNA-126 were increased after 8 weeks of smoking cessation, demonstrating variable circulating levels of microRNA in different conditions. The ratio of plasma/whole blood serotonin concentration showed significant association with oxidative stress in individuals with cardiovascular risks, and is a significant determinant of the incidence of coronary artery disease. Targeting serotonin-oxidative stress axis as a part of a holistic anti-atherothrombotic strategy is potentially benefitial in patients with atherosclerosis. Moreover, damages in the coronary endothelium affect circulating levels of endothelium-derived microRNAs. Further examination is necessary to establish the clinical significance of microRNAs.

Free Research Field

動脈硬化