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2015 Fiscal Year Final Research Report

Comprehensive study for detection of coronary endothelial dysfunction using microRNA array analysis

Research Project

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Project/Area Number 24790559
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionNagoya City University

Principal Investigator

Sugiura Tomonori  名古屋市立大学, 医学(系)研究科(研究院), 助教 (60535235)

Project Period (FY) 2012-04-01 – 2016-03-31
Keywords動脈硬化 / マイクロRNA / 血管内皮 / 酸化ストレス / 高血圧 / 喫煙 / 脂質異常 / 冠動脈
Outline of Final Research Achievements

Vascular endothelial damage was improved and plasma levels of circulating microRNA-126 were increased after 8 weeks of smoking cessation, demonstrating variable circulating levels of microRNA in different conditions. The ratio of plasma/whole blood serotonin concentration showed significant association with oxidative stress in individuals with cardiovascular risks, and is a significant determinant of the incidence of coronary artery disease. Targeting serotonin-oxidative stress axis as a part of a holistic anti-atherothrombotic strategy is potentially benefitial in patients with atherosclerosis. Moreover, damages in the coronary endothelium affect circulating levels of endothelium-derived microRNAs. Further examination is necessary to establish the clinical significance of microRNAs.

Free Research Field

動脈硬化

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Published: 2017-05-10  

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