2013 Fiscal Year Final Research Report
Qualitative assessment of the advantage of laparoscopic weight loss surgery against nonalcoholic liver disease
| Project/Area Number |
24790560
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
BABA Shigeaki 岩手医科大学, 医学部, 研究員 (90573064)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 高度肥満症 / 腹腔鏡下減量手術 / 非アルコール性肝疾患 / 肝容積 / ASQ / 肝繊維マーカー |
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| Research Abstract |
We performed laparoscopic sleeve gastrectomy against 35 patients. The average BMI dropped 45kg/m2, preoperatively, to 30kg/m2, after the operation. Comparing preoperative state to 6 months after the operation, the FD ratio increased 0.032 to 0.189(p=0.0002), the liver volume decreased 2,276ml(rt. 1,482ml, lt. 794ml) to 1,741ml(rt. 1,156ml, lt. 576ml) (p=0.008); almost the same size of healthy individuals. Type IV collagen, as hepatic fibrsis marker, dropped 4.4ng/m to 3.9ng/m in the same period of time(p=0.047). 10 cases has been diagnosed as NASH by perioperative liver biopsy and found remarkable improvement in NAS score postoperatively.
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