2013 Fiscal Year Final Research Report
Study on the mechanism of production and secretion in central nervous system by imaging mass spectrometry
| Project/Area Number |
24790567
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 内因性ジギタリス / 質量分析 / 質量顕微鏡 / 高血圧 / 生理活性物質 / 副腎 / 視床下部 |
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| Research Abstract |
The qualitative analysis of Endogenous digitalis-like factor (EDLF) is used immunohistochemistry and Liquid Chromatography mass spectrometry (LC/MS). LC/MS is applied for the liquid sample; therefore it is difficult to analyze for cell and tissue. Imaging mass spectrometry can directly analyze for cell and tissue. We confirmed the mass spectrum pattern of marinobufotoxin and marinobufagin as well as the result of LC/MS in the concentration of pictogram.
Imaging mass spectrometry should be useful analytic tool to study for EDLF.
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[Journal Article] Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction2012
Author(s)
Kamimura D, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Omori Y, Tsukamoto Y, Furutani K, Komiyama Y, Yoshika M, Takahashi H, Matsuda T, Baba A, Umemura S, Miwa T, Komuro I, Yamamoto K
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Journal Title
Eur Heart J
Volume: 33
Pages: 1408-16
DOI
Peer Reviewed
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[Journal Article] Comparison between Two Calcium Antagonists : Blood Pressure Reduction and Renal Effects in Hypertensive Patients with Type 2 Diabetes2012
Author(s)
Yokoi T, Azuma J, Nakade Y, Sanada F, Iekushi K, Yoshika M, Masuda M, Komiyama Y, Taniyama Y, Masaki H, Morishita R, Takahashi H
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Journal Title
Immunology, endocrine & metabolic agents in medicinal chemistry
Volume: 12
Pages: 152-159
Peer Reviewed
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