2014 Fiscal Year Final Research Report
Function of nitrated IL-18 in diabetes mellitus
| Project/Area Number |
24790569
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 糖尿病 |
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| Outline of Final Research Achievements |
IL-18 promotes the production of IFN and granulocyte-macrophage CSF and inhibits IL-10 production. In humans, IL-18 concentrations are reported to be increased in individuals with type 2 diabetes and in obese individuals. However, detailed functions of IL-18 in diabetes are still unclear.
The purpose of this study was to investigate the effects of oxidative modification on the IL-18 functions, and evaluate as a disease-specific marker. It was found that peroxynitrite nitrated IL-18 at tyrosine residues, resulting the dysfunction of IL-18 such as insulin signal transduction and IFN inducing ability. Furthermore, nitrated IL-18 was found in db/db mice, animal model of diabetes mellitus. These results suggested that nitrated IL-18 maybe involved in the development of diabetes mellitus. Nitrated IL-18 has the possibility to be a diabetes-specific marker because of its unique structure.
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| Free Research Field |
生化学
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