2013 Fiscal Year Final Research Report
Investigation of the effect of selective COX-2 inhibitor for discogenic pain.
| Project/Area Number |
24790579
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
SAWAJI YASUNOBU 東京医科大学, 医学部, ポストドクター (20571152)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 神経成長因子 / 椎間板性腰痛 / 選択的COX-2阻害剤 / プロスタグランジン / 軟骨変性 / 神経侵入 / 炎症 |
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| Research Abstract |
Degeneration of the disc by matrix metalloproteinases (MMPs) and following innervation of the peripheral nerve fiber by nerve growth factor (NGF) are considered as the molecular mechanism of developing discogenic pain. The effect of a selective COX-2 inhibitor, which is often used for managing low back pain in clinic, on the regulation of NGF and MMPs was investigated in isolated human intervertebral disc cells.
Inflammatory cytokine-induced NGF and MMPs expressions were augmented when the cells were treated with a selective COX-2 inhibitor, suggesting that inhibition of COX-2 activity may accelerate both disc degeneration and innervation.
These findings may need to be carefully taken into account when treating patients with discogenic pain.
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[Journal Article] Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-12013
Author(s)
Wuqikun Alimasi, Yasunobu Sawaji, Kenji Endo, Makiko Yorifuji, Hidekazu Suzuki, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
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Journal Title
Spine
Volume: volume 38, number 17
Pages: 1466-1472
DOI
Peer Reviewed
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