2013 Fiscal Year Final Research Report
Study on role of protein nitrosylation in the nitric oxide-mediated prevention of asthma
| Project/Area Number |
24790587
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Yamaguchi University (2013)
Okayama University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 予防医学 / 喘息 / 一酸化窒素 / マウス |
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| Research Abstract |
The goal of this study is to develop a novel method to prevent asthma. It is known that nitric oxide plays key roles in asthma. Nitric oxide is known to function as a bronchodilator. However, the detailed mechanisms of action remain incompletely understood. This study examined, using a murine model of asthma, the changes in the concentrations of nitric oxide-modified proteins and other nitric oxide-derived small molecules. Nitric oxide-modified proteins and other nitric oxide-derived molecules were rather increased in asthma.
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