2013 Fiscal Year Final Research Report
Dose-effect relationship between heavy-metal exposure levels and oxidative stress markers in heavy-metal exposed workers
Project/Area Number |
24790591
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hygiene
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Research Institution | Keio University |
Principal Investigator |
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Research Collaborator |
OMAE Kazuyuki 慶應義塾大学, 医学部, 教授 (60118924)
NAKANO Makiko 慶應義塾大学, 医学部, 助教 (70384906)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 産業中毒 / 酸化ストレスマーカー / 血液中鉛 / 血清インジウム / 量影響関係 |
Research Abstract |
The aim of this study was to investigate the dose-effect relationships between heavy metal exposure and oxidative stress markers. The subjects were 27 male workers in a lead secondary smelting factory, and 59 workers exposed to indium metal or indium compounds. Lead in whole blood (Pb-B) or indium in serum (In-S) was measured as an exposure index of lead or indium. Urinary 8-hydroxydeoxyguanosine (8-OHdG) and urinary 8-isoprostaglandin F2 alpha(8-iso-PGF) were determined as a DNA peroxidation stress marker and as a cell membrane peroxidation stress biomarker. Significant exposure-effect relationships were observed between Pb-B and 8-OHdG, and between Pb-B and 8-iso-PGF. Lead exposure may induce peroxidation stress on DNA and cell membrane lipid. Conversely, there were no significant relationships between In-S and two biomarkers.
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Research Products
(1 results)