2013 Fiscal Year Final Research Report
A new mechanism of alternative polyadenylation-dependent carcinogenesis
| Project/Area Number |
24790705
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NISHIDA Kensei 徳島大学, ヘルスバイオサイエンス研究部, 助教 (10624033)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ポリアデニレーション / ストレス / 発がんメカニズム |
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| Research Abstract |
Alternative polyadenylation events in HCT116 human colon cancer cell lines were analyzed using exon array and reral-time RT-PCR. We revealed that arsenite stress shorten the length of 3'UTR in JUN gene. We identified that eleven genes whose 3'UTRs were shortened in the cells knockout of a tumor suppressor gene. MB453 breast cancer cell lines preferred to use the proximal polyadenylation site of CCND1.
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Research Products
(23 results)
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[Journal Article] Oxidative stress-inducible truncated serine/arginine-rich splicing factor 3 regulates interleukin-8 production in human colon cancer cells2014
Author(s)
Kano S, Nishida K, Kurebe H, Nishiyama C, Kita K, Akaike Y, Kajita K, Kurokawa K, Masuda K, Kuwano Y, Tanahashi T, Rokutan K
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Journal Title
Am J Physiol Cell Physiol
Volume: 306(3)
Pages: C250-262
DOI
Peer Reviewed
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[Journal Article] Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells2012
Author(s)
Kurokawa K, Tanahashi T, Iima T, Yamamoto Y, Akaike Y, Nishida K, Masuda K, Kuwano Y, Murakami Y, Fukushima M, Rokutan K
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Journal Title
J Gastroenterol
Volume: 47(8)
Pages: 883-895
DOI
Peer Reviewed
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