Capsule endoscpy analysis of ulcerative colitis

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790716
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: HIGURASHI Takuma 横浜市立大学, 附属病院, 指導診療医 (90622580)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 潰瘍性大腸炎 / カプセル内視鏡

Research Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by diffuse mucosal inflammation, traditionally regarded as being limited to the colorectum. Although several gastoroduodenal lesions have also been reported recently in cases of UC, in general, small-bowel lesions in UC are believed to be extremely rare. The aim of this study was to examine the small bowel by capsule endoscopy in patients with UC.
The frequency of small-bowel lesions, the number of small-bowel lesions per patient and the capsule endoscopy score were comparatively evaluated.Almost 60% showed small-bowel lesions, and 35% had erosions. There were significant differences in the frequency of the small-bowel lesions (p < 0.001) and erosions (p = 0.009) compared with healthy volunteer. The capsule endoscopy score was correlated with the UC disease activity index (r = 0.718, p < 0.001). It was concluded that UC, a chronic inflammatory bowel disease, can also involve the small bowel.

Research Products

• [Journal Article] Risk factors for small-bowel mucosal breaks in chronic low-dose aspirin users : data from a prospective multicenter capsule endoscopy registry (2014)
  • Author(s): Endo H, Sakai E, Taniguchi L, Kessoku T, Komiya Y, Ezuka A, Kawamura H, Taguri M. Higurashi T, Ohkubo H, Yamada E, Takahashi H, Inamori M, Maeda S, Sakaguchi T, Hata Y, Nagase H, Nakajima A
  • Journal Title: Gastrointest Endosc Volume: pii: S0016-5107(14) Pages: 01292-9
  • Peer Reviewed
• [Journal Article] Visceral obesity as a risk factor for left-sided diverticulitis in Japan : a multicenter retrospective study (2013)
  • Author(s): Yamada E, Ohkubo H, Higurashi T, Sakai E, Endo H, Takahashi H, Uchida E, Tanida E, Izumi N, Kanesaki A, Hata Y, Matsuura T, Fujisawa N, Komatsu K, Maeda S, Nakajima A
  • Journal Title: Gut Liver Volume: 7(5) Pages: 522-8
  • Peer Reviewed
• [Journal Article] Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding (2013)
  • Author(s): Sakai E, Endo H, Taniguchi L, Hata Y, Ezuka A, Nagase H, Yamada E, Ohkubo H, Higurashi T, Sekino Y, Koide T, Iida H, Hosono K, Nonaka T, Takahashi H, Inamori M, Maeda S, Nakajima A
  • Journal Title: Dig Endosc Volume: 25(4) Pages: 412-20
  • Peer Reviewed
• [Presentation] Capsule endoscopic findings of ulcerative colitis patients (2012)
  • Author(s): Takuma Higurashi, Hiroki Endo, Masato Yoneda, Kunihiro Hosono, Eiji Sakai, Hirokazu Takahashi, Masahiko Inamori, Shiori Uchiyama, Takuto Kojima, Kenichi Kawana, Yutaka Natsumeda, Hajime Nagase, Atsushi Nakajima
  • Organizer: Digestive Disease Week 2012 Upper GI - Small Bowel Imaging Poster Session
  • Place of Presentation: Sandiego
  • Year and Date: 2012-05-19
• [Book] 特集I カプセル内視鏡の進歩 カプセル内視鏡による潰瘍性大腸炎の小腸病変の検出 消化器内科(56(3)) (2013)
  • Author(s): 日暮琢磨、酒井英嗣、遠藤宏樹、中島淳、永瀬肇
  • Total Pages: 262-268
  • Publisher: 科学評論社発行
• [Book] 特集 生活習慣と消化器疾患・治療薬3. 炎症性腸疾患(2 (4):) (2012)
  • Author(s): 日暮琢磨, 酒井英嗣, 中島淳
  • Total Pages: 26-34
  • Publisher: MEDICINAL