2015 Fiscal Year Final Research Report
Comprehensive analysis of dysfunctional HCV specific CD8 T cell during persistent HCV infection
| Project/Area Number |
24790720
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
Nobuhiro Nakamoto 慶應義塾大学, 医学部(信濃町), 専任講師 (40383749)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | C型肝炎ウイルス / T細胞疲弊 / 獲得免疫 |
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| Outline of Final Research Achievements |
Peripheral HCV specific CD8 T cells in patients with chronic HCV infections showed higher expressions of suppressive co-stimulation molecules such as PD-1, CTLA4, and LAG-3 compared with EBV or influenza specific CD8 T cells from the same individuals. HCV specific CD8 T cells in patients with higher viral load tended to express multiple suppressive co-stimulation molecules. Of interest, PD-1 positive HCV specific CD8 T cells produced higher TNFα and lower IL-10 compared with PD-1 negative subsets. There results suggest that HCV specific CD 8 T cells fall to be dysfunctional via the expression of multiple suppressive co-stimulation molecules during persistent HCV infection. Further study is needed to clarify the mechanism behind the immune tolerance in the liver and to overcome the HCV infection in humans.
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| Free Research Field |
肝臓免疫
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