2013 Fiscal Year Final Research Report
Analysis of mechanism of maintaining the stemness properties in human colon cancer stem cells using innovative spheroid culture system
| Project/Area Number |
24790727
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
OHATA Hirokazu 独立行政法人国立がん研究センター, 研究所, 研究員 (40570057)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | がん幹細胞 / CD44 / 大腸がん |
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| Research Abstract |
It has been proposed that cancer stem cells (CSCs) are responsible for tumor formation, therapeutic resistance and recurrence. We established the in vitro spheroid culture of CSCs from human colon cancer surgical specimens. Therefore, through our analysis of the mechanism of maintaining the stemness properties in human colon CSCs, we aimed to link our study to the development of innovative cancer therapies.
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[Journal Article] Induction of the stem-like cell regulator CD44 by Rho kinase inhibiition con ntributes to the mmaintenance of colon-initiating cells2012
Author(s)
Hirokazu Ohata, Tatsuyya Ishiguro, Yuki Aihhara, Ai Sato, Hiroaki Sakai, Shgeki Sekine, Hirokkazu Taniguchi. Takayuki Akasu, Shin Fujita, Hitoshi Nakagama, , Koji Okaamoto
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Journal Title
Cancer Research
Volume: vol.72
Pages: 5101-55110
DOI
Peer Reviewed
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