Impact of new generation drug-eluting stent on coronary vasomotion

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790732
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: TSUBURAYA Ryuji 東北大学, 大学病院, 助教 (30599882)
• Co-Investigator(Renkei-kenkyūsha): SHIMOKAWA Hiroaki 東北大学, 大学院医学系研究科, 教授 (00235681) ; YASUDA Satoshi 国立循環器病研究センター, 病院, 部門長 (00431578) ; NISHIMIYA Kensuke 東北大学, 東北メディカルメガバンク機構, 非常勤講師 (10734238) ; MATSUMOTO Yasuharu 東北大学, 大学病院, 助教 (90600528) ; TAKAHASHI Jun 東北大学, 大学病院, 講師 (00375081)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬剤溶出ステント / 異常血管反応 / Vaso vasorum

Outline of Final Research Achievements

We evaluated a vamotion in new generation drug-eluting stent (DES) implantation, everolimus-eluting stent (EES) and biolimus-eluting stent. The BES could improve an abnormal vasomotion compared with first generation DES and EES. In immunohistological analysis, enhanced inflammatory response and adventitial Vasa Vasorum (VV) formation, which were observed in first generation DES, was significantly inhibited in BES site. Furthermore, we succeeded VV imaging in vivo by optical frequency domain imaging in pigs and even in humans.

Free Research Field

循環器内科学