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2013 Fiscal Year Final Research Report

Identification of the molecular mechanisms in between adipose tissue dysfunction and metabolic syndrome

Research Project

  • PDF
Project/Area Number 24790740
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

MATSUMOTO Sahohime  東京大学, 医学部附属病院, 助教 (80570184)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords脂肪組織機能異常 / 慢性炎症 / 肥満症 / メタボリックシンドローム
Research Abstract

Obesity has become a global health and social burden. Obesity is known to induce inflammation within visceral adipose tissue, which contributes to the development of metabolic and cardiovascular disease. However, it remains unknown how adipose inflammation is initiated. In obesity, adipose tissue expands through both the hypertrophy and hyperplasia of adipocytes. We found that during adipocyte hyperplasia, adipocyte progenitors give rise to two cell populations: adipocytes and CD34+CD29+Sca-1intCD24+ adipocyte progenitor-derived proinflammatory (APDP) cells. While APDP cells appear to support angiogenesis that is tightly linked to adipogenesis, their transplantation into lean adipose tissue induced inflammation and systemic insulin resistance partly by producing proinflammatory cytokines and recruiting monocytes. Our results demonstrate that adipocyte hyperplasia triggers an inflammatory cascade through generation of APDP cells.

  • Research Products

    (15 results)

All 2014 2013 2012 Other

All Journal Article (2 results) Presentation (11 results) Book (1 results) Remarks (1 results)

  • [Journal Article] The w-3 polyunsaturated fatty acid, eicosapentaenoic acid, attenuates abdominal aortic aneurysm development via suppression of tissue remodeling Wang JH2014

    • Author(s)
      Eguchi K, Matsumoto S et.al
    • Journal Title

      Plos One

      Volume: 9(5)

  • [Journal Article] Saturated fatty acid palmitate aggravates neointima formation by promoting smooth muscle phenotypic modulation Shen2013

    • Author(s)
      H, Eguchi K, Kono N, Fujiu K, Matsumoto S et.al
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 33(11) Pages: 2596-607

  • [Presentation] Adipocyte Progenitors derived New Cell Cluster InitiateAdipose Inflammation in Obesity2014

    • Author(s)
      松本佐保姫,真鍋一郎,小室一成,永井良三
    • Organizer
      日本循環器内科学会
    • Place of Presentation
      東京
    • Year and Date
      20140321-23
  • [Presentation] 脂肪幹細胞由来の新規細胞集団の同定と病態生理学的役割の解明2013

    • Author(s)
      松本佐保姫,真鍋一郎,永井良三
    • Organizer
      日本肥満学会
    • Place of Presentation
      東京
    • Year and Date
      20131011-12
  • [Presentation] Adipocyte Progenitors derived New Cell Cluster Initiate Adipose Inflammationin Obesity2013

    • Author(s)
      松本佐保姫,真鍋一郎,永井良三
    • Organizer
      Aegene conference
    • Place of Presentation
      Greece
    • Year and Date
      20130915-20
  • [Presentation] Adipocyte Progenitors derived New Cell Cluster Initiate Adipose Inflammationin Obesity2013

    • Author(s)
      松本佐保姫,真鍋一郎,永井良三
    • Organizer
      Cell symposia
    • Place of Presentation
      Canada
    • Year and Date
      20130609-11
  • [Presentation] Adipocyte Progenitors derived New Cell Cluster InitiateAdipose Inflammation in Obesity2013

    • Author(s)
      松本佐保姫,真鍋一郎,小室一成,永井良三
    • Organizer
      日本循環器内科学会
    • Place of Presentation
      横浜
    • Year and Date
      20130315-17
  • [Presentation] Adipocyte Progenitors derived New Cell Cluster InitiateAdipose Inflammation in Obesity2013

    • Author(s)
      松本佐保姫
    • Organizer
      東京高血圧研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-09-28
  • [Presentation] Adipocyte progenitors initiateadipose inflammation in obesity2012

    • Author(s)
      松本佐保姫,真鍋一郎,永井良三
    • Organizer
      血管生物医学会
    • Place of Presentation
      徳島
    • Year and Date
      20121205-07
  • [Presentation] Adipocyte progenitor-derived proinflammatory cells link adipocyte adipocyte hyperplasia and adipose tissueinflammation2012

    • Author(s)
      松本佐保姫,真鍋一郎,永井良三,小室一成
    • Organizer
      AHA
    • Place of Presentation
      LA, USA
    • Year and Date
      20121105-06
  • [Presentation] Adipocyte progenitor cells regulateadipose tissue inflammation2012

    • Author(s)
      松本佐保姫,真鍋一郎,永井良三
    • Organizer
      肥満学会
    • Place of Presentation
      京都
    • Year and Date
      20121011-12
  • [Presentation] Adipocyte progenitor-derived proinflammatory cells link adipocyte adipocyte hyperplasia and adiposetissue inflammation2012

    • Author(s)
      松本佐保姫,真鍋一郎,永井良三
    • Organizer
      動脈硬化学会
    • Place of Presentation
      福岡
    • Year and Date
      20120719-20
  • [Presentation] Adipocyte progenitor-derived proinflammatory cells link adipocyte adipocyte hyperplasia and adipose tissue inflammation2012

    • Author(s)
      松本佐保姫,真鍋一郎,永井良三
    • Organizer
      Cell symposia
    • Place of Presentation
      Belgium
    • Year and Date
      20120705-09
  • [Book] Stromal vascular cells, Angiogenesis in Adipose Tissue, ChapterII2013

    • Author(s)
      Matsumoto S, Manabe I
    • Total Pages
      41-52
    • Publisher
      Springer
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/manabe/index.htm

URL: 

Published: 2015-06-25  

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