Prevention of Left Ventricular Remodeling after Acute Myocardial Infarction in Interleukin-17 Deficient Mice

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790788
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Kurume University
• Principal Investigator: MINAMI TOMOKO 久留米大学, 医学部, 助教 (30597430)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 生体分子 / シグナル伝達

Research Abstract

Post-infarct mortality was prevented in interleukin-17 knockout mice (IL17-KO) compared with wild-type mice. Left ventricular dysfunction, increase in LV weight to body weight ratio, and myocardial fibrosis 28 days after myocardial infarction were significantly attenuated in IL17-KO mice compared with wild-type mice. To investigate the mechanism for left ventricular remodeling inhibition in IL17-KO mice, we conducted microarray analysis. Microarray analysis revealed that the expressions of extracellular matrix related genes were lower in IL17-KO mice than those in wild-type mice. These results suggest that IL17 may play a pathogenic role in the development of left ventricular remodeling after myocardial infarction, possibly through the regulation of extracellular matrix genes expression.

Research Products

• [Journal Article] Screening for Fabry disease in patients with left ventricular hypertrophy (2013)
  • Author(s): Mawatari K, Yasukawa H, Oba T, Nagata T, Togawa T, Tsukimura T, Kyogoku S, Ohshima H, Minami T, Sakubaba H, Imaizumi T
  • Journal Title: Int J Cardiol Volume: 167(3) Pages: 1059-61
  • Peer Reviewed
• [Journal Article] Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice (2012)
  • Author(s): Ohmura H, Yasukawa H, Minami T, Sugi Y, Oba T, Nagata T, Kyogoku S, Ohshima H, Aoki H, Imaizumi T
  • Journal Title: Hypertens Res Volume: 35(11) Pages: 1063-1068
  • Peer Reviewed
• [Journal Article] Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction (2012)
  • Author(s): Oba T, Yasukawa H, Hoshijima M, Sasaki K, Futamata N, Fukui D, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Minami T, Nakamura K, Kang D, Yajima T, Knowlton KU, Imaizumi T
  • Journal Title: J Am Coll Cardiol Volume: 59(9) Pages: 838-852
  • Peer Reviewed