2013 Fiscal Year Final Research Report
Investigation on the nature of tissue remodeling in COPD lungs
| Project/Area Number |
24790795
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
SUZUKI Masaru 北海道大学, 大学病院, 助教 (10374290)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 呼吸器内科 / 慢性閉塞性肺疾患 |
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| Research Abstract |
In the lungs of chronic obstructive pulmonary disease (COPD), emphysema severity was associated with an increase in alveolar B cell and CD4 T cell infiltration whereas thickening of bronchiolar walls was associated with a decrease in total collagen and an increase in type I collagen rather than inflammatory cell infiltration. Furthermore, it was found that collagen subtypes could be quantitatively detected by quantification of forward and backward second harmonic generation (SHG) signals with multi-photon excitation microscopy, and microarray analysis showed that genes associated with TGF-beta signaling pathway were down-regulated in the thickened bronchiolar walls.
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