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2013 Fiscal Year Final Research Report

Investigation on the nature of tissue remodeling in COPD lungs

Research Project

  • PDF
Project/Area Number 24790795
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionHokkaido University

Principal Investigator

SUZUKI Masaru  北海道大学, 大学病院, 助教 (10374290)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords呼吸器内科 / 慢性閉塞性肺疾患
Research Abstract

In the lungs of chronic obstructive pulmonary disease (COPD), emphysema severity was associated with an increase in alveolar B cell and CD4 T cell infiltration whereas thickening of bronchiolar walls was associated with a decrease in total collagen and an increase in type I collagen rather than inflammatory cell infiltration. Furthermore, it was found that collagen subtypes could be quantitatively detected by quantification of forward and backward second harmonic generation (SHG) signals with multi-photon excitation microscopy, and microarray analysis showed that genes associated with TGF-beta signaling pathway were down-regulated in the thickened bronchiolar walls.

  • Research Products

    (6 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] COPDにおける末梢気道閉塞と肺気腫の関係2013

    • Author(s)
      鈴木雅
    • Journal Title

      International Review of Asthma & COPD

      Volume: 15巻 Pages: 32-36

    • Peer Reviewed
  • [Journal Article] Small airway obstruction in COPD : New insights based on micro-CT imaging and MRI imaging2013

    • Author(s)
      Hogg.JC、McDonough.JE、Suzuki.M
    • Journal Title

      Chest

      Volume: 143巻 Pages: 1436-1443

    • Peer Reviewed
  • [Presentation] Relationship between plasma amino acid levels and lung function decline in patients with COPD2013

    • Author(s)
      Suzuki.M、Makita.H、Konno.S、Nagai.K、Nishimura,M
    • Organizer
      The 23rd European Respiratory Society Annual Congress
    • Place of Presentation
      Fira Barcelona (Barcerona, Spain)
    • Year and Date
      2013-09-10
  • [Presentation] Elevated plasma adiponectin associated with lung function decline inn patients with chronic obstructive pulmonary disease2013

    • Author(s)
      Suzuki.M、Makita.H、Ostling.J、Konno.S、Nagai.K、Shimizu.K、 Maciewicz.RA、Nishimura.M
    • Organizer
      The 108th American Thoracic Society International Conference
    • Place of Presentation
      Pennsylvania Convention Center (Philadelphia, USA)
    • Year and Date
      2013-05-20
  • [Presentation] The examination of collagen remodeling in COPD using second harmonic generation microscopy2012

    • Author(s)
      Suzuki.M、Abraham.T、McDonough.JE、Elliott.WM、Hogg.JC
    • Organizer
      The 107th American Thoracic Society International Conference
    • Place of Presentation
      Moscone Center (San Francisco, USA)
    • Year and Date
      2012-05-22
  • [Presentation] Peripheral lung tissue remodeling in centrilobular emphysema2012

    • Author(s)
      Suzuki.M、McDonough.JE、Abraham.T、Walker.DC、Elliott.WM、Gosselink.JV、 Campbell.JD、Sin.DD、Hayashi.S、Cooper.JD、Hogg.JC
    • Organizer
      第52回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2012-04-22

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Published: 2015-06-25  

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