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2013 Fiscal Year Final Research Report

Resistance mechanisms of novel ALK inhibitors

Research Project

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Project/Area Number 24790798
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

SASAKI Takaaki  旭川医科大学, 医学部, 助教 (70516997)

Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsALK陽性肺癌 / アレクチニブ / 薬剤耐性
Research Abstract

Mechanisms of resistance with novel ALK tyrosine kinase, alectinib were investigated. H3122, EML4-ALK positive lung cancer cell line were treated with alectinib and showed resistance. These cell lines showed EGFR phosphorylation and MET signaling activation.
Combination therapy with EGFR tyrosine kinase inhibitor or MET inhibitor were effective for the treatment of H3122 alectinib resistance mouse xenograft model.

  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] Intrinsic and acquired resistance mechanisms of alectinib in ALK rearranged cells2014

    • Author(s)
      Yukiko Hibino1, Sasaki Takaaki1, Yoshinori Minami1, Pasi A. Janne2, Yoshinobu Ohsaki1
    • Organizer
      2Dana-Farber Cancer Institute, Boston, MA AACR annual meeting 2014
    • Place of Presentation
      1Asahikawa Medical University, Asahikawa, Japan
    • Year and Date
      20140000

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Published: 2015-06-25  

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