Respiratory neuroplastisity- upper airway patency during sleep

2015 Fiscal Year Final Research Report

• Project/Area Number: 24790803
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Chiba University
• Principal Investigator: Terada Jiro 千葉大学, 医学(系)研究科(研究院), 助教 (20400898)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 呼吸の神経可塑性

Outline of Final Research Achievements

We　analyzed　respiration in unanesthetized rodents using EMG/EEG radiotelemetry system and whole body pletysmography to evaluate respiratory change during/after hypoxia, hypercapnia, and intermittent hypoxia in each sleep-wake state. Diaphragm EMG was detected in unanesthetized rats during sleep and wakefulness. Genioglossus EMG was also detected, but artifacts caused by chewing, swallowing was contaminated in unanesthetized condition. Therefore, the respiratory change in genioglossus was not able to be evaluated. On the other hands, respiration during wakefulness and sleep after administration of novel wake-promoting agent modafinil, which is expected to promote respiration, was evaluated. But the results of the present study were not consistent with our original hypothesis that modafinil enhances ventilation with promoted wakefulness. Unexpectedly, the results showed that modafinil suppressed ventilation in room air and hypercapnic responses.

Free Research Field

呼吸器内科