2013 Fiscal Year Final Research Report
Involvement of phospholipid-related enzymes and transporters in lung diseases
| Project/Area Number |
24790805
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | 独立行政法人国立国際医療研究センター |
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Principal Investigator |
HARAYAMA TAKESHI 独立行政法人国立国際医療研究センター, 脂質シグナリングプロジェクト, 研究員 (50610218)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | リン脂質 / ホスファチジルコリン / 酵素 / 肺サーファクタント / アシル基転移酵素 / 急性肺障害 |
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| Research Abstract |
To investigate the functions of phospholipids in the lung, we generated mice that lack a phospholipid-metabolizing enzyme, LPCAT1. We investigated the role of LPCAT1 during pulmonary diseases, and found that LPCAT1-deficient mice have altered pulmonary surfactant (a surface active material that prevents alveolar collapse in the lung) function. This property rendered LPCAT1-deficient mice highly susceptible to acute lung injury.
In addition, we found how multiple phospholipid-metabolizing enzymes regulate phospholipid composition in various tissues. These findings will lead to an understanding of the relationship between various diseases and phospholipid metabolism.
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