2013 Fiscal Year Final Research Report
Regulation of transcription factor in airway epithelial cells for asthma treatment
| Project/Area Number |
24790818
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
ASAI KAZUHISA 大阪市立大学, 医学(系)研究科(研究院), 病院講師 (10382053)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 閉塞性肺疾患 / 気道炎症 / 酸化ストレス |
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| Research Abstract |
Bronchial asthma and COPD are characterized with chronic airway inflammation. To control airway inflammation intervention to individual cytokines or chemokines are now under trial. However, due to its Redundancy of cytokines or chemokines it is very hard to control airway inflammation. Mediators are under the control of transcription factor and intervention to transcription factors may be a breakthrough in disease control.
In this research supported by Grant-in-Aid for Scientific Research (KAKENHI), we have found that expression of NRF2(Nuclear factor erythrid-2-related factor 2), a transcription factor for controlling antioxidant production, in bronchial epithelial cells in COPD patients is significantly decreased compared with that of healthy non-smoking healthy subjects for the first time. Also we showed that smoking decreased expression of NRF2 in bronchial epithelial cells.
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Research Products
(16 results)
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[Presentation] COPD患者における運動耐容能と Impulse Oscillation System(IOS)のパラメータとの相関についての検討2013
Author(s)
吉井直子,金澤博,井尻尚樹,武田倫子,玉垣学也,今橋由美子,一丸之寿,浅井一久,栩野吉弘,鴨井博,平田一人
Organizer
第53回日本呼吸器学会学術講演会
Place of Presentation
東京
Year and Date
20130419-21
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[Presentation] 当院にて施行されたCTガイド下肺生検 92例の検討2013
Author(s)
中井俊之,香川直美,杉山由香里,井尻尚樹,山本典雄,玉垣学也,吉井直子,梅川加奈子,今橋由美子,永田光里,松浦邦臣,光岡茂樹,栩野吉弘,浅井一久,木村達郎,鴨井博,吉村成央,金澤博,工藤新三,平田一人
Organizer
第53回日本呼吸器学会学術講演会
Place of Presentation
東京
Year and Date
20130419-21
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