2013 Fiscal Year Final Research Report
T cell pathways involving CTLA4 contribute to acute lung injury
| Project/Area Number |
24790819
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 急性肺障害 / T細胞 / CTLA4 |
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| Research Abstract |
Acute lung injury (ALI) is a major cause of severe respiratory failure. The pathogenesis of ALI remains ill defined, and the treatment of ALI remains largely supportive. We showed that T cell pathways involving cytotoxic T lymphocyte antigen 4 (CTLA4) may modulate the inflammation in ALI. We demonstrated that rapamycin, an immunosuppressant which inhibits T cell activation and induces regulatory T cells, ameliorates inflammation in ALI. We also determined a mechanism of the specific pathways by which CTLA4 are activated in ALI. The potential therapeutic impact of manipulating T cell pathways involving CTLA4 in ALI merits further investigation.
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