2014 Fiscal Year Final Research Report
Involvement and therapeutic applications of the fibrinolytic system in bronchial asthma
Project/Area Number |
24790824
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Keio University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 気管支喘息 / uPA / PAI-2 |
Outline of Final Research Achievements |
PAI-2 is regarded as the target molecule of new asthma treatment, that is different from the fibrinolysis inhibiting activity. We have examined the possibility of asthma treatment with urokinase(uPA) as a ligand of PAI-2. In airway epithelial cell model, good results of asthma related mediators such as Eotaxin, RANTES, Eotaxin-3 in the stimulation with IL-4 and TNFα is suppressed expression in uPA concentration dependence was obtained.
|
Free Research Field |
気管支喘息
|