2014 Fiscal Year Final Research Report
The effect of chronic oxidative stress on non-genomic action of mineralocorticoid receptor in the CA1 region.
| Project/Area Number |
24790834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo (2014)
Tokyo Women's Medical University (2012-2013) |
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Principal Investigator |
MORI Fumiko 東京大学, 先端科学技術研究センター, 研究員 (80431857)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ミネラロコルチコイド受容体 / 非ゲノム作用 / 酸化ストレス |
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| Outline of Final Research Achievements |
We made chronic oxidative stress model by uninephrectomy and high salt loading to SD rat. and we found that non-genomic action of mineralocortioid receptor was diminished by chronic oxidative stressin the CA1 region of hippocampus. Further we confirmed that oxidative stress did not decrease MR expression itself, but decrease membranous MR expression.
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| Free Research Field |
高血圧
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