2014 Fiscal Year Final Research Report
Genome-wide analysis of epigenetics involved in progression of overt diabetic nephropathy
| Project/Area Number |
24790854
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 糖尿病性腎症 / エピジェネティクス / 腎疾患 / 腎臓学 / 糖尿病 |
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| Outline of Final Research Achievements |
The metabolic syndrome is characterized by abdominal obesity, dyslipidemia, hypertension and hyperglycemia. The strength of hyperglycemia condition and a period are conserved in cells by epigenetic changes as “metabolic memory”. In this study, metabolic syndrome model rats were fed on a standard diet for one year three months and the epigenetic changes which induce kidney disease were analyzed by genome-wide DNA methylation states in glomerular vascular endothelial cells. As a result, about 2,000 genes, which decreased DNA methylation at gene promoters by metabolic syndrome, were found as a candidate. This screen revealed 11 genes that were concerned with an inflammation and 6 genes that were concerned formation of angiogenetic and glomerular vascular endothelial cells.
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| Free Research Field |
腎臓病学、分子生物学
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