2014 Fiscal Year Final Research Report
Dendrin is an indication of disease activity and progression in IgA nephropathy
| Project/Area Number |
24790858
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | dendrin / ポドサイト / IgA腎症 / 慢性腎不全 / 慢性糸球体腎炎 |
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| Outline of Final Research Achievements |
IgA nephropathy (IgAN) is associated with a substantial risk of progression to end-stage renal failure. The progression of IgAN is associated with podocyte injury and that podocyte injury is related to proteinuria. The translocation of dendrin to the podocyte nucleus as well as strong cathepsin L staining were detected in the glomeruli of IgAN. The translocation of dendrin to the podocyte nuclei enhances podocyte apoptosis.
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| Free Research Field |
腎臓内科
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