Development of therapy of Alzheimer's disease using biomarker

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790869
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Hirosaki University
• Principal Investigator: WAKASAYA Yasuhito 弘前大学, 医学(系)研究科(研究院), 助教 (10598725)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アミロイド / タウ / シヌクレイン / アルツハイマー病 / レビー小体型認知症

Outline of Final Research Achievements

Aβ deposition begins from 8month in Tg2576 model mice, and from 3 month in TgCRND8 mice. Memory disturbance begins from 6 month in Tg2576 mice, and from 5 month in TgCRND8 mice. CSF Aβ42 decreased with aging. In TgTauP301L mice, tau deposition begins from 2 month, NFT begins at 8 month, and memory disturbance begins from 12 month. In TgαSYN mice, α-synuclein begin from 2 month, cytoplasmic inclusions begin from 7 month, and behavior disturbance was found from 10.5 month. With protein deposition oin brain, behavioral disturbance wsd induced in theses model mice.

Free Research Field

神経内科