Establishment of a therapeutic strategy based on axonal ion chanel in diabetic polyneuropathy.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790874
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Chiba University
• Principal Investigator: SEKIGUCHI Yukari 千葉大学, 医学(系)研究科(研究院), 助教 (10568653)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖尿病性神経障害 / 軸索機能検査

Outline of Final Research Achievements

It is difficult to evaluate the activity of ion channel in the leg, especially sensory nerves which often disturbed mainly in the patients with polyneuropathy. The aim of this study is to establish the nerve excitability technique in the sensory nerve at the lower extremities and to provide information about membrane potentials and axonal ion channel function for neuropathy patients, especially diabetic polyneuropathy. We established the technique of nerve excitability test in sural nerve using by near nerve needles.
We also tested the patients with diabetic polyneuropathy using this technique and suggest the disfunction of ion channels in diabetic polyneuropathy. Our study suggests that the nerve excitability test with near nerve needles may be useful to evaluate the activity of ion channel at sensory nerve in lower extremities and helpful to clarify the mechanism of diabetic polyneuropathy.

Free Research Field

神経内科