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2013 Fiscal Year Final Research Report

Evaluation of neuropathic pain system using pain-related evoked potentials with C fiber selective electrical stimulation

Research Project

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Project/Area Number 24790901
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionClinical research Center, Chiba-East National Hospital, National Hospital Organization

Principal Investigator

ISOSE Sagiri  独立行政法人国立病院機構(千葉東病院臨床研究センター), その他部局等, その他 (80466698)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords神経障害性疼痛 / 疼痛関連誘発電位 / 末梢神経障害
Research Abstract

We investigated patterns of changes in A delta- and C-mediated brain responses in neuropathic pain, using pain-related evoked potentials (PREPs) with intra-epidermal electrical stimulation (IES) for evaluation of neuropathic pain system. Patients with neuropathic pain have increased C/A delta fiber-PREP amplitude ratios, possibly due to decreased inhibition of the A delta to C nociceptive system leading to generation of neuropathic pain. PREPs with IES could be a useful tool to evaluate changes in neural responses and interaction of the A delta- and C-mediated pain pathways in neuropathic pain patients.

  • Research Products

    (12 results)

All 2014 2013 2012

All Journal Article (5 results) Presentation (7 results)

  • [Journal Article] Bortezomib-induced neuropathy : axonal membrane depolarization precedes development of neuropathy2014

    • Author(s)
      Nasu S, Misawa S, Nakaseko C, Shibuya K, Isose S, Sekiguchi Y, Mitsuma S, Ohmori S, Iwai Y, Beppu M, Shimizu N, Ohwada C, Takeda Y, Fujimaki Y, Kuwabara S
    • Journal Title

      Clin Neurophysiol

      Volume: 125 Pages: 381-7

    • DOI

      10.1016/j.clinph.2013.07.014

  • [Journal Article] Somatotopic representation of pain in the primary somatosensory cortex (S1) in humans2013

    • Author(s)
      Omori S, Isose S, Otsuru N, Nishihara M, Kuwabara S, Inui K, Kakigi R
    • Journal Title

      Clin Neurophysiol

      Volume: 124 Pages: 1422-30

    • DOI

      10.1016/j.clinph.2013.01.006

  • [Journal Article] Prominent fatigue in spinal muscular atrophy and spinal and bulbar muscular atrophy : evidence of activity-dependent conduction block2013

    • Author(s)
      Noto Y, Misawa S, Mori M, Kawaguchi N, Kanai K, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Beppu M, Ohmori S, Nakagawa M, Kuwabara S
    • Journal Title

      Clin Neurophysiol

      Volume: 124 Pages: 1893-8

    • DOI

      10.1016/j.clinph.2012.12.053.

  • [Journal Article] Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis2012

    • Author(s)
      Kanai K, Shibuya K, Sato Y, Misawa S, Nasu S, Sekiguchi Y, Mitsuma S, Isose S, Fujimaki Y, Ohmori S, Koga S, Kuwabara S
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83 Pages: 734-8

    • DOI

      10.1136/jnnp-2011-301782

  • [Journal Article] Differences in excitability between median and superficial radial sensory axons2012

    • Author(s)
      Fujimaki Y, Kanai K, Misawa S, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Ohmori S, Noto Y, Kugio Y, Shimizu T, Matsubara S, Lin CS, Kuwabara S
    • Journal Title

      Clinical Neurophysiol

      Volume: 123(7) Pages: 1440-5

    • DOI

      10.1016/j.clinph.2011.11.002.

  • [Presentation] POEMS 症候群における神経障害性疼痛 : 疼痛関連誘発電位検査による検討2013

    • Author(s)
      磯瀬沙希里(他8名)
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県立県民文化ホール
    • Year and Date
      20131107-09
  • [Presentation] PATHOPHYSIOLOGY OF NEUROPATHIC PAIN IN POEMS SYNDROME : STUDY OF PAIN-RELATED EVOKED POTENTIALS2013

    • Author(s)
      Sagiri Isose et al.,(他9名)
    • Organizer
      Biennial Meeting of the Peripheral Nerve Society
    • Place of Presentation
      Saint.Malo, France
    • Year and Date
      20130629-0703
  • [Presentation] POEMS症候群における疼痛発生の機序 : 表皮内小径線維刺激による誘発電位からの検討2013

    • Author(s)
      磯瀬沙希里(他9名)
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      20130529-0601
  • [Presentation] 疼痛関連誘発電位を用いた神経障害性疼痛における中枢性評価へのアプローチ2012

    • Author(s)
      磯瀬沙希里(他10名)
    • Organizer
      第42回日本臨床神経生理学会学術大会
    • Place of Presentation
      京王プラザホテル)
    • Year and Date
      20121108-10
  • [Presentation] CIDPの電気診断における遠位CMAP持続時間 : 低周波フィルターの影響2012

    • Author(s)
      磯瀬沙希里(他13名)
    • Organizer
      第23回日本末梢神経学会学術大会
    • Place of Presentation
      九州大学医学部百年講堂)
    • Year and Date
      20120831-0901
  • [Presentation] The effects of low-cut filtering on CMAP duration in electrodiagnosis of CIDP2012

    • Author(s)
      Sagiri Isose et al.,(他11 名)
    • Organizer
      PNS/Inflammatory Neuropathy Consortium Meeting
    • Place of Presentation
      Rotterdam, The Netherlands
    • Year and Date
      20120624-27
  • [Presentation] 表皮内電気刺激による痛覚誘発電位を用いた神経障害性疼痛の病態2012

    • Author(s)
      磯瀬沙希里(他11名)
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      20120522-25

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Published: 2015-06-25  

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