2013 Fiscal Year Final Research Report
Identification of the antibody induced by the new vaccine against Alzheimer's diseasese induces
| Project/Area Number |
24790902
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
NIIMI Naoko 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (90405043)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | DNAワクチン / 抗体特異性 / アルツハイマー |
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| Research Abstract |
The molecular mechanisms of Alzheimer's disease remain unknown. A recent study suggested that amyloid oligomer not the senile plaques formed by Ab cause strong synaptic injyurious effects. In this study, we demonstrated that the anti-Ab oligomer antibody is potentiated and the Ab oligomer reduced by developing new DNA vaccines. This vaccines is worth examining in preclinical and clinical trials.
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