2013 Fiscal Year Final Research Report
The mechanism of environmental effects on obesity
| Project/Area Number |
24790905
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
KANEKO Keizo 東北大学, 大学病院, 助教 (60546141)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 糖尿病 / 肥満 |
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| Research Abstract |
Recently there has bee explosive increase in metabolic disorders such as obesity and diabetes. The life style changes (e.g.,sedentary behavior, overconsumption of fast food and irregular circadian rhythm)are related to this phenomenon.
Therefore as a research approach, focusing the living environment is a very important to study metabolic disorders.We added enriched environment(e.g., tunnels, shelters and a wheel) to a mouse cage) and investigated the effect on metabolism.Introduction of enriched environment decreased the body weight, fat weight and blood glucose levels.Because brain plays an important role regulating the whole metabolism and is affected by the environmental changes. We are now analyzing what is going on in the brain at the molecular level to approach the mechanism.
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