2013 Fiscal Year Final Research Report
Physiological analysis of SLC22A18 gene associated with visceral fat accumulation
| Project/Area Number |
24790909
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | メタボリックシンドローム / 連鎖解析 / 内臓脂肪 / トランスポーター |
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| Research Abstract |
In this study, to investigate the physiological functions of SLC22A18, an orphan transporter, in visceral fat accumulation and hepatic lipid accumulation, we analyzed SLC22A18-genetically modified mice and screened the endogenous substrate of SLC22A18. Animal experiments revealed that SLC22A18 positively regulates fat accumulation and triglyceride accumulation in liver. We found bilirubin as a candidate of SLC22A18 substrates. These results indicate the novel function of SLC22A18 and suggest the possibility of SLC22A18 as a therapeutic target of metabolic disorder.
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