2013 Fiscal Year Final Research Report
Response to feeding-induced endoplasmic reticulum stress in the liver regulated by Sdf2l1 maintains glucose and lipid homeostasis
| Project/Area Number |
24790913
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肥満 / 糖尿病 / インスリン抵抗性 / シャペロン |
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| Research Abstract |
We have revealed the role of a co-chaperone, Sdf21, in a refed state in the liver. We further focused on interaction with BiP, a chaperone playing a pivotal role in endoplasmic reticulum (ER), which was elevated under endoplasmic reticulum (ER) stress in hepatocytes. In a mouse model of obesity and diabetes, however, expression of Sdf2l1 in the liver was down-regulated at the level of transcription, suggesting its pathophysiological importance via inability to respond to excessive ER stress. Actually ablation of Sdf2l1 in adult mice showed phenotypes similar to those in mice with the gene knocked down temporarily, which we analyzed before, adding further evidence to indicate the importance of hepatic Sdf2l1 in maintenance of systemic glucose and lipid homeostasis.
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[Presentation] 新規小胞体ストレス調節因子Sdf2l1 による肝臓でのインスリン感受性調節作用の検討2012
Author(s)
笹子 敬洋, 植木 浩二郎, 寺井 愛, 岩根 亜弥, 小林 正稔, 岡崎 由希子, 大杉 満, 鈴木亮, 窪田 直人, 戸辺 一之, 門脇 孝
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
横浜
Year and Date
2012-05-19
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