2013 Fiscal Year Final Research Report
Molecular mechanisms of diabetic lipemia in streptozotocin-treated mice
| Project/Area Number |
24790915
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ホルモン感受性リパーゼ / リポ蛋白リパーゼ / インスリン |
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| Research Abstract |
The molecular mechanism of diabetic lipemia in the setting of insulin deficiency is not fully understood. We have previously found that the plasma level of triglycerides is lower in hormone-sensitive lipase (HSL) deficient mice than in wild-type mice when they are challenged with streptozotocin. The current study was aimed at elucidating the molecular mechanism of diabetic lipemia through the detailed analysis of HSL-deficient mice in the insulin-deficient status. We found that the enzymatic activity and mRNA levels of lipoprotein lipase (LPL) were not significantly different between wild-type and HSL-deficient mice in the insulin-deficient status. Other factors that regulate LPL activity in vivo or other pathways such as intestinal lipid absorption may explain the phenotypic difference, which are currently under investigation.
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