2013 Fiscal Year Final Research Report
Role of hepatic proliferation on disorder of hepatic glucose metabolism
| Project/Area Number |
24790919
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Kanazawa University |
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Principal Investigator |
KIMURA Kumi 金沢大学, 脳・肝インターフェースメディシン研究センター, 特任助教 (60409472)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肝糖代謝 / 肥満・インスリン抵抗性 / 肝細胞増殖 |
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| Research Abstract |
Obesity-Insulin resistance is known to increase of hepatic gluconeogenesis and hepatic steatosis associated with enlarged liver. To understand the role of control of hepatic proliferation on disorder of hepatic glucose metabolism, we generated the liver specific Cyclin D1 knockout (KO) mouse. In this KO mouse treated with high fat diet or db/db-background, there was no significant difference in body weight and blood glucose level under ad lib fed conditions. To explain more fully, we will performed hyperinsulinemic-euglycemic clamps in these mice.
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[Journal Article] Histidine augments the suppression of hepatic glucose production by central insulin action2013
Author(s)
Kumi KIMURA, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H
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Journal Title
Diabetes
Volume: 62
Pages: 2266-2267
Peer Reviewed
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[Journal Article] The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR432013
Author(s)
Kimura I, Ozawa K, Inoue D, Imamura T, Kumi KIMURA, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G
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Journal Title
Nature Communications
Volume: 4
Pages: 1829
DOI
Peer Reviewed
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[Journal Article] Endoplasmic Reticulum Stress Inhibits STAT3-dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation2012
Author(s)
Kumi KIMURA, Tomoko YAMADA, Michihiro MATUSMOTO, Yoshiaki KIDO, Tetsuya HOSOOKA, Shun-ichiro ASAHARA, Tomokazu MATSUDA, Tsuguhito OTA, Hiroshi WATANABE, Yoshimichi SAI, Kenichi MIYAMOTO, Shuichi KANEKO, Masato KASUGA, Hiroshi INOUE
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Journal Title
Diabetes
Volume: 61
Pages: 61-73
Peer Reviewed
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