2013 Fiscal Year Final Research Report
Role of novel variants of PGC-1alpha in the regulation of energy metabolism
| Project/Area Number |
24790924
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | エネルギー・糖質代謝異常 / PGC-1α / 肥満 |
|---|
| Research Abstract |
The transcriptional coactivator PGC-1alpha is implicated in the regulation of body mass and insulin sensitivity; however, its contribution to these conditions is unclear. Two recently identified PGC-1alpha variants are transcribed from an alternative promoter and induced by exercise in skeletal muscle. Here we show that mice lacking these variants develop age-dependent obesity and insulin resistance. Although the total PGC-1alpha abundance in skeletal muscle was unaltered under static conditions, exercise-induced increases in total PGC-1alpha and energy expenditure were attenuated in the mutant mice. These results suggest that PGC-1alpha variants are responsible for exercise-induced PGC-1alpha upregulation, which in turn plays an important role in controlling fat mass and insulin sensitivity via the regulation of energy expenditure during exercise.
|
