2013 Fiscal Year Final Research Report
The role of zinc transporter in adipocyte differentiation
| Project/Area Number |
24790936
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 亜鉛トランスポーター / 脂肪細胞 / 褐色化 / エネルギー消費 |
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| Research Abstract |
We investigated the role of ZIP13 in adipocyte tissues, and recently we obtained the following preliminary data.
(1) Zip13-KO mice showed a reduction in subcutaneous WAT mass and visceral WAT mass as expected, while intriguingly the expression levels of several BAT markers including Ucp1 were increased in the subcutaneous WAT from Zip13-KO mice. (2) This browning phenotype of Zip13-KO cells occurs in a cell autonomous manner: namely, preadipocytes derived from subcutaneous WAT of Zip13-KO mice significantly induced the expression of several BAT markers in ex vivo cultures in response to a brown induction cocktail. (3) Zip13-KO mice showed a remarkable obesity-resistant phenotype when fed on a high fat diet. (4) Enhancement of insulin sensitivity was observed in Zip13-KO mice.
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Author(s)
Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, AbeH, Toyofuku Y, Tamaki M, Ogihara T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H
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Journal Title
J Clin Invest
Volume: (in press)
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[Journal Article] Molecular pathogenesis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins2014
Author(s)
BinBH, Hojyo S, HosakaT, Bhin J, KanoH, MiyaiT, Ikeda M, Kimura-Someya T, Shirouzu M, Cho EG, Fukue K, Kambe T, Ohashi W, Kim KH, Seo J, Choi DH, Nam YJ, Hwang D, Fukunaka A, Fujitani Y, Yokoyama S, Superti-Furga A, Ikegawa S, Lee TR and Fukada T
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Journal Title
EMBO Molecular Medicine
Volume: (in press)
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[Journal Article] The diabetes susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance2013
Author(s)
TamakiM, FujitaniY, HaraA, Uchida T, TamuraY, Takeno K, Kawaguchi M, Watanabe T, Ogihara T, Fukunaka A, Shimizu T, Mita T, Kanazawa A, MO. Imaizumi, Abe T, Kiyonari H, Hojyo S, Fukada T, Kawauchi T, Nagamatsu S, Hiraono T, Kawamori R, Watada H
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Journal Title
J Clin Invest
Volume: 123(10)
Pages: 4513-4524
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